Selected publications (#first authors, *corresponding authors):

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• Yu Jiang#, Haidi Huang#, Jiangying Liu#, Dan Luo, Rongzi Mu, Jianghong Yuan, Jihong Lin, Qiyue Chen, Wufan Tao, Ling Yang, Man Zhang, Pingping Zhang, Fengqin Fang, Jianming Xu, Qingqiu Gong, Zhiping Xie, Yongchun Zhang*. Hippo cooperates with p53 to maintain foregut homeostasis and suppress the malignant transformation of foregut basal progenitor cells. PNAS. 2024 Mar 5;121(10):e2320559121.

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•Haidi Huang#, Yu Jiang#, Jiangying Liu, Dan Luo, Jianghong Yuan, Rongzi Mu, Xiang Yu, Donglei Sun, Jihong Lin, Qiyue Chen, Xinjing Li, Ming Jiang, Jianming Xu, Bo Chu, Chengqian Yin, Lei Zhang, Youqiong Ye, Bo Cao, Qiong Wang*, Yongchun Zhang*. Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool. Nature Communications. 2024, May 15;15(1):4124.

 

•Yongchun Zhang#,*, Dimitris Karagiannis#, Helu Liu#, Mi Lin, Yinshan Fang, Ming Jiang, Xiao Chen, Supriya Suresh, Haidi Huang, Junjun She, Feiyu Shi, Jiangying Liu, Dan Luo, J Carlos Angel, Guangtan Lin, Patrick Yang, Wael El-Rifai, Alexander Zaika, Anthony E Oro, Kuancan Liu, Anil K Rustgi, Timothy C Wang, Chao Lu*, Jianwen Que*. Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy. Science Advances. 2024 Oct 11;10(41):eadq0479.

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•Bingnan Zhao#, Xiuwei Yu#, Jintong Shi#, Shuangyu Ma#, Shizhao Li#, Haitao Shi, Shoubing Xia, Youqiong Ye, Yongchun Zhang*, Yanhua Du*, Qiong Wang*. Nature Communications. 2024 Nov 22;15(1):10123.

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•Jiangying Liu#, Dan Luo#, Haidi Huang, Rongzi Mu, Jianghong Yuan, Ming Jiang, Chuwen Lin, Honggang Xiang, Xinhua Lin, Haihan Song, Yongchun Zhang*. Hippo cooperates with p53 to regulate lung airway mucous cell metaplasia. Disease Models & Mechanisms. 2024 Nov 1;17(11):dmm052074.

 

•Yongchun Zhang, Ying Yang, Ming Jiang, Sarah Xuelian Huang, Wanwei Zhang, Denise Al Alam, Soula Danopoulos, Munemasa Mori, Ya-Wen Chen, Revathi Balasubramanian, Susana M. Chuva de Sousa Lopes, Carlos Serra, Monika Bialecka, Eugene Kim, Sijie Lin, Ana Luisa Rodrigues Toste de Carvalho, Paul N. Riccio, Wellington V. Cardoso, Xin Zhang, Hans-Willem Snoeck, Jianwen Que. 3D Modeling of Esophageal Development using Human PSC-Derived Bas al Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018 Oct 4;23(4):516-529.e5.

 

•Yongchun Zhang*, Dominique Bailey, Patrick Yang, Eugene Kim, Jianwen Que*. The development and stem cells of the esophagus.  Development. 2021 Mar 29;148(6): dev193839.

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•Yongchun Zhang, Jianwen Que. BMP signaling in development, stem cells, and diseases of the gastrointestinal tract. Annual Review of Physiology. 2020 Feb 10:82:251-273.

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•Dominique D Bailey#, Yongchun Zhang#, Benjamin J van Soldt#, Ming Jiang, Supriya Suresh, Hiroshi Nakagawa, Anil K Rustgi, Seema S Aceves, Wellington V Cardoso, Jianwen Que. Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus. Development. 2019 Dec 4;146(23):dev178855.

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•Yongchun Zhang, Ming Jiang, Eugene Kim, Sijie Lin, Kuancan Liu, Xiaopeng Lan, Jianwen Que. Development and stem cells of the esophagus. Seminars in Cell & Developmental Biology. 2017 Jun:66:25-35.

 

Others publications:​​

•Yongchun Zhang, Tzong-jen Sheu, Donna Hoak, Jie Shen, Matthew J Hilton, Michael J Zuscik, Jennifer H Jonason, Regis J O'Keefe. CCN1 Regulates Chondrocyte Maturation and Cartilage Development. Journal of Bone and Mineral Research. 2016 Mar;31(3):549-59.

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•Yongchun Zhang, Regis J O'Keefe, Jennifer H Jonason. BMP-TAK1 (MAP3K7) induces adipocyte differentiation through PPARγ signaling. Journal of Cellular Biochemistry. 2017 Jan;118(1):204-210.

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•Ming Jiang, Haiyan Li, Yongchun Zhang, Ying Yang, Rong Lu, Kuancan Liu, Sijie Lin, Xiaopeng Lan, Haikun Wang, Han Wu, Jian Zhu, Zhongren Zhou, Jianming Xu, Dong-Kee Lee, Lanjing Zhang, Yuan-Cho Lee, Jingsong Yuan, Julian A. Abrams, Timothy C. Wang, Antonia R. Sepulveda, Qi Wu, Huaiyong Chen, Xin Sun, Junjun She, Xiaoxin Chen, Jianwen Que. Transitional basal cells at the squamous-columnar junction generate Barrett's esophagus. Nature. 2017 Oct 26;550(7677):529-533.

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•Weiwei Cui, Meng Guo, Dong Liu, Peng Xiao, Chuancheng Yang, Haidi Huang, Chunhui Liang, Yinghong Yang, Xiaolong Fu, Yudan Zhang, Jiaxing Liu, Shuang Shi, Jingjing Cong, Zili Han, Yunfei Xu, Lutao Du, Chengqian Yin, Yongchun Zhang, Jinpeng Sun, Wei Gu, Renjie Chai, Shu Zhu, Bo Chu. Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition. 2024 Nature Cell Biology. Jan;26(1):124-137. doi: 10.1038/s41556-023-01314-6.

 

•Eugene Kim, Ming Jiang, Huachao Huang, Yongchun Zhang, Natalie Tjota, Xia Gao, Jacques Robert, Nikesha Gilmore, Lin Gan, Jianwen Que. Isl1 regulation of Nkx2.1 in the early foregut epithelium is required for trachea-esophageal separation and lung lobation. Developmental Cell. 2019 Dec 16;51(6):675-683.e4.

 

•Zhili Hou, Qi Wu, Xin Sun, Huaiyong Chen, Yu Li, Yongchun Zhang, Munemasa Mori, Ying Yang, Jianwen Que, Ming Jiang. Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea. Development. 2019 Feb 11;146(3):dev171496.

 

•Zhili Hou, Qi Wu, Xin Sun, Huaiyong Chen, Yu Li, Yongchun Zhang, Munemasa Mori, Ying Yang, Jianwen Que, Ming Jiang. Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea. Development. 2019 Feb 11;146(3):dev171496.

 

•Sijie Lin, Kuancan Liu, Yongchun Zhang, Ming Jiang, Rong Lu, Christopher J Folts, Xia Gao, Mark D Noble, Tingting Zhao, Zhongren Zhou, Xiaopeng Lan, Jianwen Que. Pharmacological targeting of p38 MAP-Kinase 6 (MAP2K6) inhibits the growth of esophageal adenocarcinoma. Cellular Signalling. 2018 Nov:51:222-232.