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Yongchun Zhang, PhD

Principal Investigator, Associate Professor

School of Life Sciences and Biotechnology, Shanghai Jiao Tong University

https://life.sjtu.edu.cn/teacher/En/yongchunzhang

University Profile

Research

Research

We are utilizing various experimental approaches, including mouse genetics, 3D organoids, molecular technologies, and bioinformatics, to study stem cells, development, homeostasis, regeneration, and cancer in the gastrointestinal tract (the esophagus, stomach, and intestine) and the respiratory tract (lung).

Publications

Google scholar profile https://scholar.google.com/citations?user=l_4VHj8AAAAJ&hl=en

（# co-first authors, *corresponding authors）

2020-present

Yu Jiang#, Haidi Huang#, Jiangying Liu#, Dan Luo, Rongzi Mu, Jianghong Yuan, Jihong Lin, Qiyue Chen, Wufan Tao, Ling Yang, Man Zhang, Pingping Zhang, Fengqin Fang, Jianming Xu, Qingqiu Gong, Zhiping Xie, Yongchun Zhang*. Hippo cooperates with p53 to maintain foregut homeostasis and suppress the malignant transformation of foregut basal progenitor cells. PNAS. 2024 Mar 5;121(10):e2320559121.
Yongchun Zhang*, Dominique Bailey, Patrick Yang, Eugene Kim, Jianwen Que*. The development and stem cells of the esophagus. Development. 2021 Mar 29;148(6):dev193839.
Weiwei Cui, Meng Guo, Dong Liu, Peng Xiao, Chuancheng Yang, Haidi Huang, Chunhui Liang, Yinghong Yang, Xiaolong Fu, Yudan Zhang, Jiaxing Liu, Shuang Shi, Jingjing Cong, Zili Han, Yunfei Xu, Lutao Du, Chengqian Yin, Yongchun Zhang, Jinpeng Sun, Wei Gu, Renjie Chai, Shu Zhu, Bo Chu. Gut microbial metabolite facilitates colorectal cancer development via ferroptosis inhibition. Nature Cell Biology. 2024 Jan;26(1):124-137. doi: 10.1038/s41556-023-01314-6.

Before 2020

Yongchun Zhang, Ying Yang, Ming Jiang, Sarah Xuelian Huang, Wanwei Zhang, Denise Al Alam, Soula Danopoulos, Munemasa Mori, Ya-Wen Chen, Revathi Balasubramanian, Susana M. Chuva de Sousa Lopes, Carlos Serra, Monika Bialecka, Eugene Kim, Sijie Lin, Ana Luisa Rodrigues Toste de Carvalho, Paul N. Riccio, Wellington V. Cardoso, Xin Zhang, Hans-Willem Snoeck, Jianwen Que. 3D Modeling of Esophageal Development using Human PSC-Derived Bas al Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018 Oct 4;23(4):516-529.e5.
Yongchun Zhang, Jianwen Que. BMP signaling in development, stem cells, and diseases of the gastrointestinal tract. Annual Review of Physiology. 2020 Feb 10:82:251-273.
Dominique D Bailey#, Yongchun Zhang#, Benjamin J van Soldt#, Ming Jiang, Supriya Suresh, Hiroshi Nakagawa, Anil K Rustgi, Seema S Aceves, Wellington V Cardoso, Jianwen Que. Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus. Development. 2019 Dec 4;146(23):dev178855.
Yongchun Zhang, Tzong-jen Sheu, Donna Hoak, Jie Shen, Matthew J Hilton, Michael J Zuscik, Jennifer H Jonason, Regis J O'Keefe. CCN1 Regulates Chondrocyte Maturation and Cartilage Development. Journal of Bone and Mineral Research. 2016 Mar;31(3):549-59.
Yongchun Zhang, Ming Jiang, Eugene Kim, Sijie Lin, Kuancan Liu, Xiaopeng Lan, Jianwen Que. Development and stem cells of the esophagus. 2017 Seminars in Cell & Developmental Biology. 66, 25-35.
Zhili Hou, Qi Wu, Xin Sun, Huaiyong Chen, Yu Li, Yongchun Zhang, Munemasa Mori, Ying Yang, Jianwen Que, Ming Jiang. Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea. Development. 2019 Feb 11;146(3):dev171496.
Yongchun Zhang, Regis J O'Keefe, Jennifer H Jonason. BMP-TAK1 (MAP3K7) induces adipocyte differentiation through PPARγ signaling. Journal of Cellular Biochemistry. 2017 Jan;118(1):204-210.
Ming Jiang, Haiyan Li, Yongchun Zhang, Ying Yang, Rong Lu, Kuancan Liu, Sijie Lin, Xiaopeng Lan, Haikun Wang, Han Wu, Jian Zhu, Zhongren Zhou, Jianming Xu, Dong-Kee Lee, Lanjing Zhang, Yuan-Cho Lee, Jingsong Yuan, Julian A. Abrams, Timothy C. Wang, Antonia R. Sepulveda, Qi Wu, Huaiyong Chen, Xin Sun, Junjun She, Xiaoxin Chen, Jianwen Que. Transitional basal cells at the squamous-columnar junction generate Barrett's esophagus. Nature. 2017 Oct 26;550(7677):529-533.
Eugene Kim, Ming Jiang, Huachao Huang, Yongchun Zhang, Natalie Tjota, Xia Gao, Jacques Robert, Nikesha Gilmore, Lin Gan, Jianwen Que. Isl1 regulation of Nkx2.1 in the early foregut epithelium is required for trachea-esophageal separation and lung lobation. Developmental Cell. 2019 Dec 16;51(6):675-683.e4.
Zhili Hou, Qi Wu, Xin Sun, Huaiyong Chen, Yu Li, Yongchun Zhang, Munemasa Mori, Ying Yang, Jianwen Que, Ming Jiang. Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea. Development. 2019 Feb 11;146(3):dev171496.
Sijie Lin, Kuancan Liu, Yongchun Zhang, Ming Jiang, Rong Lu, Christopher J Folts, Xia Gao, Mark D Noble, Tingting Zhao, Zhongren Zhou, Xiaopeng Lan, Jianwen Que. Pharmacological targeting of p38 MAP-Kinase 6 (MAP2K6) inhibits the growth of esophageal adenocarcinoma. Cellular Signalling. 2018 Nov:51:222-232.